Quantitative Analysis of Butyric Acid-Induced Nuclear Ultrastructual Alterations of Human Lung Giant Cell Carcinoma Cells by Digital Image Processing / 第三军医大学学报

The effects of butyric acid (BA) on nuclear ultrastructure of human lung giant cell carcinoma (Strain PLA-801 D) were studied with the digital image processing.It was found that the length of the nuclear circumference of the tumor cells incubated with 2mmol BA for 4 days was approximately equal to that of the control, whereas the nuclear area increased 1.4 times. It suggested that the nuclear profile tended to decome more regular. In addition, the nuclear optical density in the experimental group decreaed significantly compring with that of the control. This finding indicated that the chromatin granules within the nuclei were decreased by virtue of BA.BA may have a biological effect of reverse-transformation on the malignant cells.